What is bActivate?
bActivate is a diagnostic aid for the detection and clearance of dormant uterine infections in mares. Dormant infections have a significant negative effect on fertility.
Facilitate mare pregnancy
Up to 15% of all mares struggle to get in foal. Recent investigations have demonstrated that dormant bacterial infections ín the uterus are a major cause. Dormant bacteria are difficult to diagnose by standard techniques and highly tolerant to antibiotic. Efficient handling thus requires re-activation of the bacteria. This can be achieved by instillation of bActivate, a bacterial growth medium, into the uterus. bActivate has been tested by the therio group at Hagyard Equine Medical Institute, the world’s largest equine hospital in Kentucky who basically normalized mare fertility by including bActivate into the standard repro work-up.
Bacterial infections in the uterus can cause reduced fertility in the mare. Bacteria gain access to the uterus through the cervix, due to poor conformation or during breeding or foaling. Healthy young mares clear bacteria rapidly. In mares with compromised uterine defense mechanisms bacteria can establish an infection in the uterus. If the infection is unnoticed or left untreated, the infection may become chronic. The most commonly isolated bacteria from such conditions are Streptococcus equi subspecies zooepidemicus (Strep. zoo). In the chronically infected mare Strep. zoo can establish an infection deep within the uterine lining (endometrium). Strep zoo appear to lower its metabolic rate during chronic infection, thus complicating diagnostics and antimicrobial treatment dependent of active bacterial growth.
bActivate is a growth medium enabling detection of chronic subclinical uterine infections associated with Strep. zoo in mares. If a chronic infection with Strep. zoo is present in the endometrium it will be activated when bActivate is instilled in the uterus. Activated Strep. zoo will thus become available for standard microbial diagnostic procedures.