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Insights from a Landmark German Study: The Bacterial Spectrum in Mare Uterine Health


A recent comprehensive study published in the Journal of Equine Veterinary Science in February 2024 provides an unprecedented look at the bacterial agents commonly found in the uterus of mares, and their significant implications on fertility. This study, analyzing 28,887 endometrial swab samples, is a monumental step towards understanding and enhancing mare reproductive health.

The Study’s Core Findings

Key bacteria identified and their prevalence rates are as follows:

  • β-hemolytic Streptococci: Dominating the findings, these bacteria were present in an overwhelming 79.7% of positive samples. Known for their role in causing endometritis, their high prevalence underscores the importance of targeted interventions.
  • Escherichia coli variatio haemolytica: Found in 5.2% of the samples, indicating a significant but less prevalent role in uterine infections compared to streptococci.
  • Escherichia coli (severe growth): Accounted for 4.3% of the samples, highlighting a notable presence in the uterine microbial ecosystem.
  • Klebsiella pneumoniae: Present in 3.9% of the samples, these bacteria add to the complex challenge of managing mare fertility.
  • Candida species: Making up 2.9% of positive samples, emphasizing the need to consider fungal as well as bacterial pathogens in treatment strategies.
  • Pseudomonas aeruginosa and Staphylococcus aureus: Found in 2.0% and 1.5% of the samples respectively, illustrating a wider range of pathogens that can impact uterine health.

Overall, 25.9% of the cultured samples showed growth of potentially pathogenic bacteria, illustrating the commonality of uterine infections in mares and emphasizing the need for vigilant management.

Implications for Mare Fertility Management

This study not only maps out the predominant bacteria affecting mare fertility but also serves as a call to action for more precise diagnostic and treatment approaches. Understanding the specific pathogens at play allows for more targeted and effective interventions, potentially reducing the overuse of broad-spectrum antibiotics and addressing the challenge of antimicrobial resistance.

Moving Forward: A New Chapter in Equine Reproductive Health

The German study’s findings represent a significant leap in our understanding of equine reproductive health, offering a detailed picture of the bacterial landscape within the mare’s uterus. By leveraging these insights, the equine breeding community can take informed steps towards improving fertility management strategies, ultimately leading to healthier mares and more successful breeding outcomes.


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bActivate has been tested by the therio group at Hagyard Equine Medical Institute, the world’s largest equine hospital in Kentucky who basically normalized mare fertility by including bActivate into the standard repro work-up.


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  • Success! After 3 years of hardship

    I used bActivate in 2016 and after one covering got a COLT foal in 2017 (after 3 years of hardship ie mare went in foal but never managed to produce a live foal).

    Breeder Mary Davison,
    Cathrinestown Stud Farm, Leixlip, Ireland

  • Potent new tool for the problem mare!

    bActivate enabled us to identify chronically infected mares, which were found to be clean on culture and cytology using routine diagnostics. We will use it for our problem mares in the coming season.

    Drs. Anja Rosenbrock and Meta Osborne, Tinnakill House, Ireland – www.tinnakill.com​

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