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What is bActivate?

bActivate is a sterile growth medium to be used as a diagnostic aid for the detection of chronic subclinical uterine infections in mares

Facilitate mare pregnancy

Ten percent of all mares struggle to get in foal. Now two Danish researchers have discovered that dormant streptococcal bacteria may be the likely cause. To re-activate the infection, instillation of bActivate, a bacterial growth medium, facilitate diagnostics and treatment eventually enabling barren mares to get in foal. bActivate has been tested by the therio group at Hagyard Equine Medical Institute, the world’s largest equine hospital in Kentucky who basically normalized mare fertility by including bActivate into the normal repro work-up.

Background information

Bacterial infections in the uterus can cause reduced fertility in the mare. Bacteria gain access to the uterus through the cervix, due to poor conformation or during breeding or foaling. Healthy young mares clear bacteria rapidly. In mares with compromised uterine defense mechanisms bacteria can establish an infection in the uterus. If the infection is unnoticed or left untreated, the infection may become chronic. The most commonly isolated bacteria from such conditions are Streptococcus equi subspecies zooepidemicus (Strep. zoo). In the chronically infected mare Strep. zoo can establish an infection deep within the uterine lining (endometrium). Strep zoo appear to lower its metabolic rate during chronic infection, thus complicating diagnostics and antimicrobial treatment dependent of active bacterial growth.

Product description

bActivate is a growth medium enabling detection of chronic subclinical uterine infections associated with Strep. zoo in mares. If a chronic infection with Strep. zoo is present in the endometrium it will be activated when bActivate is instilled in the uterus. Activated Strep. zoo will thus become available for standard microbial diagnostic procedures.


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