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bActivate is a growth medium enabling detection of chronic subclinical uterine infections associated with S. zoo in mares. If a chronic infection with S. zoo is present in the endometrium it will be activated when bActivate is instilled in the uterus. Activated S. zoo will thus become available for standard microbial diagnostic procedures.
Some farms use bActivate as a screening tool to improve diagnosis of endometritis and treatment on all open mares during the non-breeding season, hereby optimizing chances to establish a pregnancy as early as possible in the following breeding season.
Repeated uterine infections indicate compromised uterine defense mechanisms predisposing for establishment of infections – acute as well as chronic. As chronic infections can be hard to identify bActivate should be considered for this group of problem mares.
Endometrial fibrosis is induced by ongoing endometrial inflammation. Presence of beta-hemolytic streptococci within the endometrium is expected to induce endometrial inflammation, hereby increasing uterine fibrosis, and consequently decreasing fertility. If endometrial fibrosis can be minimized the number of foals each mare can produce in a lifetime is expected to increase.
If bActivate is instilled in the uterus of a mare chronically infected with Strep zoo, the subclinical inactive infection will be activated without systemic effects on the mare like fever, in appetence or discomfort. If the mare is heavily infected marked clinical signs of endometritis will be present (uterine discharge and accumulation of intrauterine fluid/exudates).
bActivate has been tested in barren mares, with a fully involuted uterus. We do not recommend the use of bActivate in mares post foaling until full uterine involution has taken place.
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