bActivate

10% percent of all mares struggle to get in foal

bActivate is a bacterial growth medium able of re-activating dormant streptococcal infections in the uterus of brood mares. Re-activation enables diagnostics, treatment and subsequent breeding. Veterinarians at Kentucky’s Hagyard Equine Medical Institute, one of the world’s largest equine practices, have successfully tested the product.

Timeline culture, activation and potential treatment

Optimize your chances for pregnancy

5-15% of all mares are not pregnant at the end of the breeding season, despite breeding to fertile stallions and supervised by experienced veterinarians.

“bActivate enabled us to identify chronically infected mares, which were found to be clean on culture and cytology using routine diagnostics. We will use it for our problem mares in the coming season.”
www.tinnakill.com

Drs. Anja Rosenbrock and Meta Osborne, Tinnakill House, Ireland

Facilitate mare pregnancy

Ten percent of all mares struggle to get in foal. Now two Danish researchers have discovered that dormant streptococcal bacteria may be the likely cause. To re-activate the infection, instillation of bActivate, a bacterial growth medium, facilitate diagnostics and treatment eventually enabling barren mares to get in foal. bActivate has been tested by the therio group at Hagyard Equine Medical Institute, the world’s largest equine hospital in Kentucky who basically normalized mare fertility by including bActivate into the normal repro work-up.
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Subclinical infection with dormant strep

One of the most frequent causes of infectious endometritis in the mare is Streptococcus equi subspecies zooepidemicus (Strep zoo). An estimated 5% of mares carry a subclinical Strep zoo infection caused by dormant Strep zoo residing deep in the endometrium (Nielsen, 2005; Petersen et al., 2009). Dormant Strep zoo are very hard to diagnose and treat with antimicrobials due to their low metabolic rate. bActivate can re-activate dormant Strep zoo, enabling diagnostics and clearing.

It should be noted that bActivate will only be a diagnostic aid if the mare is chronically infected with Strep zoo. See “Product information” or “When to use bActivate

Nielsen, J.M. (2005). Endometritis in the mare: a diagnostic study comparing cultures from swab and biopsy. Theriogenology. 64, 510-518.

Petersen, M. R., Nielsen, J. M., Lehn-Jensen, H. and Bojesen, A. M. (2009). Streptococcus equi subspecies zooepidemicus resides deep in the chronically infected endometrium of mares, Clinical Theriogenology 1, 393-409.

Petersen, M. R., Lu, K., Christoffersen, M., Nielsen, J. M., Troedsson, M.H.T. and Bojesen, A. M. (2013) Impact of activation and subsequent antimicrobial treatment of dormant endometrial streptococci in the Thoroughbre problem mare – a descriptive field study. Abstract and Poster, Society for Theriogenology Annual Meeting, August 4th-8th. Louisville, Kentucky.

The problem mares

bActivate has been tested in a highly selected group of problem mares. The open mares selected for the study had a breeding history of at least three barren cycles, but some had been barren for years. Mares had been bred to different stallions with proven fertility and under supervison of professional repro vet management. All mares in the study had poor endometrial quality (Kenney score 2b or 3). Pregnancy and live foal rates in this selected group of mares is expected to be below 30% (Bosh et al., 2009). All mares were activativated by uterine instillation of bActivate and treated with antimicrobials if bacteria were isolated. Of the 64 mares tested and bred, 53 (83%) became pregnant and 73% delivered a live foal (Petersen et al., 2013).

In other words, bActivate allowed diagnosis, enabled treatment and to a large degree normalized fertility.

Bosh KA, Powell D, Shelton B, Zent W. (2009). Reproductive performance measures among Thoroughbred mares in central Kentucky, during the 2004 mating season. Equine Vet J. 41, 883-888.

Petersen, M. R., Lu, K., Christoffersen, M., Nielsen, J. M., Troedsson, M.H.T. and Bojesen, A. M. (2013). Impact of activation and subsequent antimicrobial treatment of dormant endometrial streptococci in the Thoroughbre problem mare – a descriptive field study, Abstract and Poster, Society for Theriogenology Annual Meeting, August 4th-8th. Louisville, Kentucky

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